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In addition to stating that estimands should be used, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines also emphasize the importance of considering intercurrent events when defining the scientific question of interest and underline key principles for handling missing data [3]

Participant protection is the central priority throughout

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If these conditions are not met, the importation may constitute a criminal offence

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Individual response : As with any supplement, individual responses to DSIP may vary